研究業績 of Iwasato Takuji

研究業績

原著論文（太字：主要論文）

１．
Singer, P., Yee, BK, Feldon, J., Iwasato, T., Itohara, S., Grampp, T., Prenosil, G., Benke, D., Mohler, H., Boison, D.  Altered mnemonic functions and resistance to NMDA receptor antagonism by forebrain conditional knockout of glycine transporter 1.
Neuroscience (in press).

２．
Takeuchi, S., Yamaki, N., Iwasato, T., Negishi, M., Katoh, H.  Beta 2-chimaerin binds to EphA receptors and regulates cell migration.
FEBS Letters  583, 1237-1242. (2009).

３　
Iwasato, T., Inan, M., Kanki, H., Erzurumlu, R.S., Itohara, S., Crair, M.C.  Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
J. Neurosci. 28, 5931-43. (2008).

４.
Araya, R., Kudo, M., Kawano, M., Ishii, K., Hashikawa, T., Iwasato, T., Itohara, S., Terasaki, T., Oohira, A., Mishina, Y., Yamada, M.  BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier.
Mol Cell Neurosci. 38, 417-30. (2008).

５.
Iwasato, T.*, Katoh, H., Nishimaru, H., Ishikawa, Y., Inoue, H., Saito, Y.M., Ando, R., Iwama, M., Takahashi, R., Negishi, M.& Itohara, S.  Rac-GAP α-Chimerin Regulates Motor-Circuit Formation as a Key Mediator of EphrinB3/EphA4 Forward Signaling.
Cell 130, 742-753. (2007).
* The Corresponding Author

６.
Zeller, A., Crestani, F., Camenisch, I., Iwasato, T., Itohara, S., Fritschy, J.-M. & Rudolph, U. Cortical glutamatergic neurons mediate the motor sedative action of diazepam. 
Mol. Pharmacol. 73, 282-91. (2008).

7.
Hirota, Y., Ohshima, T., Kaneko, N., Ikeda, M., Iwasato, T., Kulkarni, A.B., Mikoshiba, K., Okano, H. & Sawamoto, K. Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone.
J. Neurosci. 27, 12829-12838. (2007).

8.
Li, T., Ren, G., Lan, J.Q., Iwasato, T., Itohara, S., Fredholm, B.B., Simon, R.P. & Boison, D. Adenosine kinase, a target for the prediction and prevention of epileptogenesis.  
J. Clinic. Invest. 118, 571-82. (2008).

9.
Earnheart, J.C., Schweizer, C., Crestani, F., Iwasato, T., Itohara, S., Mohler, H. & Lüscher, B.  GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of chronic trait anxiety and depression states.  
J. Neurosci.27, 3845-54. (2007).

10.
Ohshima, T. Hirasawa, M. Tabata, H. Mutoh, T. Adachi, T. Suzuki, H. Saruta, K. Iwasato, T. Itohara, S. Hashimoto, M. Nakajima, K. Ogawa, M. Kulkarni, A.B. and Mikoshiba, K.  Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.  
Development 134, 2273-82. (2007).

11.
Tanaka, K.F., Takebayashi, H., Yamazaki, Y., Ono, K., Naruse, M., Iwasato, T., Itohara, S., Kato, H. & Ikenaka, K.  The Murine Model of Alexander Disease:  Analyses of GFAP Aggregate Formation and Its Pathological Significance.  Glia 55, 617-631 (2007).

12.
Cappello, S., Attardo, A., Wu, X., Iwasato, T., Itohara, S., Wilsch-Bräuninger, M., Eilken, H.M., Rieger, M.A., Schroeder, T.T., Huttner, W.B., Brakebusch, C. & Götz, M.  The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. 
Nature Neurosci. 9, 1099-1107 (2006).

13.
Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW.  Pathological Cell-Cell Interactions Elicited by a Neuropathogenic Form of Mutant Huntingtin Contribute to Cortical Pathogenesis in HD Mice.
Neuron 46, 433-444 (2005).

14.
Lee, L.-J., Iwasato, T. Itohara, S., Erzurumlu, R.  Exuberant Thalamocortical Axon Arborization in Cortex-Specific NMDAR1 Knockout Mice.
J. Comp. Neurol.  485, 280-292 (2005).

15.
Tomioka, R. Okamoto, K. Furuta, T. Fujiyama, F. Yanagawa, Y. Obata, K. Iwasato, T. Kaneko, T. Tamamaki, N.  Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex.
Eur. J. Neurosci.  21, 1587-1600 (2005).

16.
Iwasato, T.+, Nomura, R., Ando, R., Ikeda, T., Tanaka, M and Itohara, S.+  Dorsal  Telencephalon-Specific Expression of Cre Recombinase in PAC Transgenic Mice.
Genesis  38, 130-138  (2004)
+ The Corresponding Authors

17.
Yuhki, M., Yamada, M., Kawano, M., Iwasato, T., Itohara, S., Yoshida, H., Ogawa, M., Mishina, Y.  BMP Receptor Signaling is Necessary for Hair Follicle Cycling and Hair Shaft Differentiation in Mice.
Development  131, 1825-1833  (2004).

18.
Inoue, H., Tsukita, K., Iwasato, T., Suzuki, Y., Tomioka, M., Tateno, M., Nagao, M., Misawa, H., Saido, T.C., Miura, M., Itohara, S., Takahashi, R.  The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.
EMBO J.  22, 6665-6674  (2003).

19.
Datwani, A.*, Iwasato, T.*+, Itohara, S., and Erzurumlu, R.S.+,  Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function in excitatory cortical neurons.
J. Neurosci. 22, 9171-9175  (2002).
*  The first two authors contributed equally to this work.    
+ The Corresponding Authors

20.
Datwani, A., Iwasato, T., Itohara, S., and Erzurumlu, R.S.  NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex.
Mol. Cell Neurosci. 21: 477-92  (2002).

21.
Metzger, F., Repunte-Canonigo, V., Matsushita, S., Akemann, W., Diez-Garcia, J., Ho, C.S., Iwasato, T., Grandes, P., Itohara, S., Joho, R.H., and Knöpfel, T.  Transgenic mice expressing a pH and Cl- sensing yellow-fluorescent protein under the control of a potassium channel promoter.
Eur. J. Neurosci. 15, 40-50  (2002).

22.
Iwasato, T., Datwani, A., Wolf, A.M., Nishiyama, H., Taguchi, Y., Tonegawa, S., Knöpfel, T., Erzurumlu, R.S. and Itohara, S.  Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex.  
Nature  406, 726-731  (2000).  

23.
Iwasato, T., Erzurumlu, R.S., Chen, D.F., Huerta, P.T., Sasaoka, T., Ulupinar, E. and Tonegawa, S. NMDA receptor dependent refinement of somatosensory maps.  
Neuron  19, 1201-1210  (1997).

24.
Iwasato, T., Kanari, Y., Shimizu, A., Honjo, T. and Yamagishi, H.  Transforming growth factor-β induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation.
Immunol. Lett.  39, 173-178  (1994).

25.
Iwasato, T., Shimizu, T., Kanari, Y. and Yamagishi, H.  Molecular characterization of extrachromosomal circular DNAs from an embryonal carcinoma cell line induced to differentiate into neuron-like cells in vivo.
Cell Struct. Funct.  18, 261-266  (1993).

26.
Arakawa, H., Iwasato, T., Hayashida, H., Shimizu, A., Honjo, T. and Yamagishi, H.  The complete murine immunoglobulin class switch region of the  heavy chain gene - Hierarchic repetitive structure and recombination breakpoints.
J. Biol. Chem.  268, 4651-4655  (1993).

27.
Iwasato, T., Arakawa, H., Shimizu, A., Honjo, T. and Yamagishi, H. Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolysaccharide.
J. Exp. Med.  175, 1539-1546  (1992).

28.
Iwasato, T. and Yamagishi, H.  Novel excision products of T cell receptor γ gene rearrangements and developmental stage specificity implied by the frequency of nucleotide insertions at signal joints.
Eur. J. Immunol. 22, 101-106. (1992).

29.
Shimizu, T., Iwasato, T. and Yamagishi, H.  Deletions of immunoglobulin Cκ region characterized by the circular excision products in mouse splenocytes.
J. Exp. Med.  173, 1065-1072. (1991).

30.
Iwasato, T., Shimizu, A., Honjo, T. and Yamagishi, H.  Circular DNA is excised by immunoglobulin class switch recombination.
Cell  62, 143-149  (1990).

31.
Toda, M., Fujimoto, S., Iwasato, T., Takeshita, S., Tezuka, K., Ohbayashi, T. and Yamagishi, H.  Structure of extrachromosomal circular DNAs excised from T-cell antigen receptor alpha and delta-chain loci.
J. Mol. Biol.  202, 219-231  (1988).




総　説

1.
岩里琢治 (1999)
イオンチャンネル型グルタミン酸受容体の変異マウス
脳の科学　1999年増刊号　207-212頁

2.
岩里琢治 (2000)
体性感覚野のバレル形成におけるNMDA型グルタミン酸受容体の役割：大脳皮質特異的NMDAR1(ζ1)ノックアウトマウスを用いた解析
実験医学　18巻17号　2343-2346頁　株式会社羊土社

3.
岩里琢治、糸原重美 (2003)
マウス遺伝学による神経回網精緻化の研究
生体の科学（2003年樹状突起特集）54巻2号138-145頁

4.
岩里琢治 (2004)
齧歯類バレル構造の活動依存的発達
蛋白質核酸酵素（増刊号）　大森治紀、澁木克栄、野田亮、山森哲雄編「神経回路の機能発現のメカニズム」
49巻3号　351-357頁　　共立出版

5.
岩里琢治 (2006)
体性感覚野（バレル野）発達の分子・細胞メカニズム
実験医学（2006年９月増刊号）狩野方伸、高田昌彦、伊佐正編「感覚受容から認知, 記憶・学習, 行動までの脳機能研究の新展開」
24号15号　60-67頁　　株式会社羊土社

6.
岩里琢治 (2007)
左右の手足の使い分けを可能にする神経回路形成の仕組み
MedicalBio　2007年11月号　10-11頁　　株式会社オーム社

7.
岩里琢治 (2008)
αキメリンは，エフリン－Ephシグナルの鍵メディエーターとして，運動系神経回路形成を制御する
実験医学　26巻3号405-408頁　　 株式会社羊土社





著　書

1.
岩里琢治  (2002)
「神経活動依存的メカニズムによる脳回路発達 」
渡辺雅彦編   みる見るわかる脳・神経科学入門講座（下）　 
73-87頁　　株式会社羊土社

2.
岩里琢治　(2004)
大脳皮質神経回路形成のメカニズムをタンパク質、遺伝子レベルで探る-マウス体性感覚（バレル）野をモデル系として-
柳原大、内藤久士編
「運動とタンパク質・遺伝子」
50-65頁　　有限会社ナップ

3.
Erzurumlu, R.S. and Iwasato, T.  (2006)
Patterning of the Somatosensory Maps with NMDA receptors.  
Erzurumlu, R.S., Guido, W. and Molner Z. ed.  Development and Plasticity in Sensory Thalamus and Cortex.  　ｐ．158-182．　Spinger





特許出願

１．
岩里琢治，糸原重美，高橋良輔，井上治久
名称「エフリン－Eph受容体シグナル伝達制御剤及びエフリン－Eph受容体シグナル伝達機構に異常を有するマウス」
出願番号　2007-217576
出願人　独立行政法人理化学研究所
出願日　平成19年8月23日